More often than not, a person missing as a result of foul play will be killed if not rescued in the first 48 hours after the abduction. This actuarial statistic is taken as gospel by struggling lawyer Tom Redmond when Redmond's Washington Post reporter daughter, Jane, disappears. Before she vanished, Jane was investigating the purported sexual misconduct of powerful Senator Gleason, who years ago destroyed her father's career as a district attorney. Now Tom believes the senator has hired a former CIA assassin to do away with Jane. Enlisting the help of former biker Mike Tubbs, Tom sets off on a 48-hour rampage of criminal trespass, kidnapping, assault, grand theft, burglary, torture and murder, racing up and down the east coast with the duct tape-wrapped senator in tow. Meanwhile, Jane makes her own escape, running half-naked around a Hudson River island, fighting snakes and psychopaths.